Description

Cyclohexanecarboxylic Acid, 2-Amino-, Ethyl Ester, Hydrochloride, (1R,2S)- is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound, with CAS number 180979-17-3, is valued for its defined stereochemistry and functional groups, which make it a critical building block for creating complex, optically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Utilized as a building block in catalytic and stoichiometric asymmetric synthesis to introduce the (1R,2S)-configured amino acid ester moiety.
• Peptidomimetics Research: Serves as a constrained, non-natural amino acid derivative for the design and synthesis of peptide analogs with enhanced metabolic stability.
• Agrochemical Development: Employed in the synthesis of chiral active ingredients for crop protection products, where specific stereochemistry is crucial for efficacy.
• Catalyst and Ligand Preparation: Used as a precursor for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and for exploring new synthetic pathways.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 2-Amino-, Ethyl Ester, Hydrochloride, (1R,2S)-
CAS No.	180979-17-3
Molecular Formula	C10H20ClNO2
Molecular Weight	221.72 g/mol
Synonyms	(1R,2S)-2-Aminocyclohexanecarboxylic Acid Ethyl Ester Hydrochloride; Ethyl (1R,2S)-2-Aminocyclohexanecarboxylate Hydrochloride; (1R,2S)-2-Amino-1-cyclohexanecarboxylic Acid Ethyl Ester HCl; trans-2-Aminocyclohexanecarboxylic Acid Ethyl Ester Hydrochloride (specified isomer); Ethyl trans-2-aminocyclohexane-1-carboxylate hydrochloride; (1R,2S)-ACHC-OEt·HCl; A chiral cyclohexyl glycine derivative
EINECS	Contact for details

Quality Control

Our Cyclohexanecarboxylic Acid, 2-Amino-, Ethyl Ester, Hydrochloride, (1R,2S)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (1R,2S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.