Description

o-Acetyl-n-Carbobenzoxyhydroxylamine is a specialized bifunctional protecting group reagent used in advanced organic synthesis. This compound is critical for the selective protection of hydroxylamine functionalities, enabling complex multi-step reactions in sensitive molecule construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of hydroxylamine groups during the multi-step synthesis of drug candidates, particularly in the development of hydroxamic acid-based therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to protect N-terminal hydroxylamine derivatives, preventing unwanted side reactions.
• Agrochemical Research: Employed in the development of novel herbicides and fungicides where hydroxylamine motifs are integral to the bioactive molecule.
• Chemical Biology & Probe Development: Facilitates the synthesis of chemical probes and affinity labels used to study enzyme function and protein interactions.
• Material Science Precursor: Serves as a building block for polymers and advanced materials requiring specific amine-oxide functionalities.
• Custom Synthesis & Contract Manufacturing: A valuable tool for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.

Basic Information

Product Name	o-Acetyl-n-Carbobenzoxyhydroxylamine
CAS No.	180798-01-0
Molecular Formula	C10H11NO4
Molecular Weight	209.20 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-O-acetylhydroxylamine; O-Acetyl-N-Cbz-hydroxylamine; Z-NH-OAc; Cbz-NH-OAc; Carbobenzyloxyamino acetate; (Benzyloxycarbonylamino) acetate; N-Carbobenzyloxy-O-acetylhydroxylamine; Acetic acid N-[(benzyloxy)carbonyl]hydrazide (related form)
EINECS	Contact for details

Quality Control

Our o-Acetyl-n-Carbobenzoxyhydroxylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.