Description

1-Methyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate is a high-value triflate ester derivative of a substituted tetrahydropyridine, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile electrophilic intermediate, enabling the introduction of the 1-methyl-1,2,3,6-tetrahydropyridin-4-yl moiety into complex molecular architectures under mild conditions. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for constructing active pharmaceutical ingredients (APIs), agrochemicals, and other specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and neurological disorder research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides requiring specific heterocyclic frameworks.
• Ligand & Catalyst Preparation: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional organic materials and monomers for specialty polymers.
• Cross-Coupling Reactions: Acts as an effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme activity.

Basic Information

Product Name	1-Methyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate
CAS No.	180692-27-7
Molecular Formula	C8H12F3NO3S
Molecular Weight	259.25 g/mol
Synonyms	1-Methyl-4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine; 1-Methyl-1,2,3,6-tetrahydropyridin-4-yl triflate; 4-(Trifluoromethanesulfonyloxy)-1-methyl-1,2,3,6-tetrahydropyridine; N-Methyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate; 1-Methyl-4-(triflyloxy)-1,2,3,6-tetrahydropyridine; 180692-27-7; 1-Methyl-1,2,3,6-tetrahydro-4-pyridinyl trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our 1-Methyl-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided and available upon request, supporting compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.