Description

1-Bromo-5-Fluoro-2-Methoxy-3-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials who require reliable access to high-quality, well-characterized intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and bromine substituents for bioactivity.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro and halogen groups.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups allow for selective displacement, enabling further functionalization of the benzene core.

Basic Information

Product Name	1-Bromo-5-Fluoro-2-Methoxy-3-Nitrobenzene
CAS No.	179897-92-8
Molecular Formula	C7H5BrFNO3
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-4-fluoro-5-methoxy-1-nitrobenzene; 3-Bromo-6-fluoro-2-methoxynitrobenzene; Benzene, 1-bromo-5-fluoro-2-methoxy-3-nitro-; 5-Fluoro-2-methoxy-3-nitro-1-bromobenzene; 4-Fluoro-5-methoxy-2-nitro-1-bromobenzene; 1-Bromo-5-fluoro-2-methoxy-3-nitrobenzene; 179897-92-8
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Fluoro-2-Methoxy-3-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by techniques including HPLC, GC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.