Description

4-Chloro-2-(Trifluoromethyl)-6-Iodoquinazoline is a high-value, multi-functional halogenated quinazoline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and trifluoromethyl substituents, makes it an exceptionally versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted kinase inhibitors and other small-molecule drug candidates, leveraging the quinazoline core for biological activity.
• Agrochemical Research: Used to develop new herbicides and fungicides, where the halogen and trifluoromethyl groups can enhance bioavailability and environmental stability.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs or semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a molecular probe or a tagging reagent in bioconjugation chemistry, utilizing the reactive iodo and chloro sites.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide orthogonal sites for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorinated Compound Synthesis: The trifluoromethyl group is a valuable motif for improving metabolic stability and lipophilicity in lead optimization.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)-6-Iodoquinazoline
CAS No.	179598-70-0
Molecular Formula	C9H3ClF3IN2
Molecular Weight	357.48 g/mol
Synonyms	6-Iodo-4-chloro-2-(trifluoromethyl)quinazoline; 4-Chloro-6-iodo-2-(trifluoromethyl)quinazoline; Quinazoline, 4-chloro-6-iodo-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-4-chloro-6-iodoquinazoline; 179598-70-0; 4-Chloro-2-trifluoromethyl-6-iodoquinazoline
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-(Trifluoromethyl)-6-Iodoquinazoline is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical characterization including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure it meets your precise research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.