Description

6-Acetoxy-4-Chloroquinazoline is a high-purity, advanced pharmaceutical intermediate characterized by its specific quinazoline backbone functionalized with acetoxy and chloro substituents. This compound is critical for its role as a versatile building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel quinazoline-based drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Used in academic and industrial R&D for constructing complex heterocyclic compounds due to its reactive chloroquinazoline core.
• Agrochemical Development: Potential intermediate in the research and synthesis of new agrochemicals and plant protection agents.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	6-Acetoxy-4-Chloroquinazoline
CAS No.	179246-11-8
Molecular Formula	C10H7ClN2O2
Molecular Weight	222.63 g/mol
Synonyms	4-Chloro-6-acetoxyquinazoline; 6-Acetoxy-4-chloroquinazoline; 4-Chloro-6-quinazolinyl acetate; Quinazoline, 4-chloro-6-acetoxy-; 179246-11-8; 6-Acetoxy-4-chloro-quinazoline
EINECS	Contact for details

Quality Control

Our 6-Acetoxy-4-Chloroquinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment supports applications requiring material for research, development, and pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.