Description

Tetrakis[(S)-(-)-n-(p-Dodecylphenylsulfonyl)Prolinato]Dirhodium(II) is a highly specialized chiral dirhodium(II) carboxylate catalyst, distinguished by its sulfonylated prolinate ligands. This compound matters for its exceptional ability to facilitate highly enantioselective transformations, offering researchers and process chemists a powerful tool for constructing complex chiral molecules with precise stereocontrol. It is primarily needed by the pharmaceutical, agrochemical, and fine chemical industries for advanced asymmetric synthesis, including cyclopropanation, C-H insertion, and other carbenoid transfer reactions critical for developing active pharmaceutical ingredients (APIs) and high-value intermediates.

Application

• Asymmetric Cyclopropanation: A key catalyst for the enantioselective synthesis of cyclopropane rings, a privileged structural motif in many bioactive compounds.
• C-H Functionalization: Enables selective carbenoid insertion into C-H bonds for the direct, atom-economical construction of C-C bonds in complex molecules.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral intermediates in the development of novel APIs, including antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in the synthesis of enantiomerically pure herbicides, fungicides, and pesticides where specific stereochemistry is essential for activity and environmental safety.
• Fine Chemical and Fragrance Manufacturing: Applied in the creation of chiral flavor and fragrance ingredients that require specific olfactory profiles.
• Methodology Development in Academia: A valuable reagent for research laboratories exploring new asymmetric catalytic reactions and mechanisms.
• Scale-up Process Chemistry: Suitable for optimization and pilot-scale reactions due to its defined structure and consistent catalytic performance.

Basic Information

Product Name	Tetrakis[(S)-(-)-n-(p-Dodecylphenylsulfonyl)Prolinato]Dirhodium(II)
CAS No.	179162-34-6
Molecular Formula	C92H136N4O16Rh2S4
Molecular Weight	~1910.0 g/mol (Contact for exact details)
Synonyms	Dirhodium(II) tetrakis[(S)-(-)-N-(p-dodecylphenylsulfonyl)prolinate]; (S)-(-)-N-(p-Dodecylbenzenesulfonyl)proline dirhodium(II) tetramer; Rh2(S-DOSP)4; Dirhodium(II) (S-DOSP)4; Chiral Dirhodium Catalyst Rh2(S-DOSP)4; Tetrakis[(S)-N-(4-Dodecylphenylsulfonyl)prolinato]dirhodium; Asymmetric Dirhodium Catalyst
EINECS	Contact for details

Quality Control

Our Tetrakis[(S)-(-)-n-(p-Dodecylphenylsulfonyl)Prolinato]Dirhodium(II) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot is characterized by advanced analytical techniques, including HPLC, NMR, and elemental analysis, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain optimal catalytic performance and shelf life.

Specification

Item	Specification
Appearance	Green to dark green solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	~10.8% (Theoretical)
Solubility	Soluble in dichloromethane, chloroform, toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.