Description

Tetrakis[(R)-(+)-n-(p-Dodecylphenylsulfonyl)Prolinato]Dirhodium(II) is a highly specialized chiral dirhodium(II) carboxylate catalyst, distinguished by its unique sulfonylated prolinate ligands. This compound matters for its exceptional ability to facilitate highly enantioselective carbenoid transformations, such as cyclopropanations and C-H insertions, with superior stereocontrol and catalytic efficiency. It is a critical reagent for pharmaceutical R&D chemists and fine chemical manufacturers who require precise asymmetric synthesis to build complex molecular architectures.

Application

• Asymmetric Cyclopropanation: A premier catalyst for the enantioselective synthesis of cyclopropane rings, key structural motifs in many active pharmaceutical ingredients (APIs) and agrochemicals.
• Enantioselective C-H Functionalization: Enables the direct, stereocontrolled insertion of carbenoids into C-H bonds, streamlining synthetic routes to chiral intermediates.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of chiral drugs, particularly for constructing challenging stereocenters with high optical purity.
• Methodology Development in Academia: A valuable tool for organic chemists in universities and research institutes exploring new catalytic asymmetric reactions.
• Fine Chemical and Fragrance Production: Applicable in the synthesis of enantiomerically pure flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Tetrakis[(R)-(+)-n-(p-Dodecylphenylsulfonyl)Prolinato]Dirhodium(II)
CAS No.	178879-60-2
Molecular Formula	C92H140N4O16Rh2S4
Molecular Weight	1918.29 g/mol
Synonyms	Dirhodium(II) tetrakis[(R)-(+)-n-(p-dodecylphenylsulfonyl)prolinate]; (R)-Rh2(DOSP)4; Rh2(S-DOSP)4; Dirhodium(II) (R)-DOSP; Tetrakis[(R)-(-)-N-(p-Dodecylphenylsulfonyl)prolinato]dirhodium(II); Rh2(R-DOSP)4; Dirhodium tetra(N-(p-dodecylbenzenesulfonyl)-(R)-prolinate); Chiral Dirhodium Catalyst (R-DOSP)
EINECS	Contact for details

Quality Control

Every batch of our chiral dirhodium catalysts is produced and tested under strict quality management protocols to ensure consistent high performance and enantioselectivity. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as Rhodium content, enantiomeric purity, and spectroscopic identity. Our quality systems support development under cGMP guidelines for pharmaceutical applications, ensuring reliable and reproducible results in your most demanding asymmetric syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when possible to maintain optimal catalytic activity. Keep the container tightly sealed to prevent exposure to moisture.

Specification

Item	Specification
Appearance	Green to blue-green solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	10.7 - 11.2 %
Specific Rotation [α]D20	Contact for details
Solubility	Soluble in dichloromethane, chloroform; slightly soluble in toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.