Description

Fmoc-D-4-Fluorophe CAS NO 177966-64-2 is a high-purity, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group, specifically designed for solid-phase peptide synthesis (SPPS). This chiral building block is critical for introducing the D-isomer of 4-fluorophenylalanine into peptide chains, enabling the creation of novel peptides with enhanced metabolic stability, altered binding affinity, and specific biological activity. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic research focused on developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise synthesis of custom peptides.
• Pharmaceutical Research & Development: For incorporating fluorinated amino acids into novel drug candidates to improve pharmacokinetic properties and receptor selectivity.
• Peptidomimetic Design: Used to create stable peptide analogs where the fluorine atom modulates electronic properties and conformational stability.
• Biochemical & Structural Studies: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Antibody-Drug Conjugate (ADC) Linker/Payload Construction: May be utilized in the synthesis of specialized peptide linkers or cytotoxic peptide payloads.
• Academic & Contract Research: Serves as a fundamental reagent in university laboratories and CROs for chemical biology and medicinal chemistry projects.

Basic Information

Product Name	Fmoc-D-4-Fluorophe CAS NO 177966-64-2
CAS No.	177966-64-2
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-D-4-fluorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-D-phenylalanine; Fmoc-4-F-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid; N-α-Fmoc-4-fluoro-D-phenylalanine; Fmoc-D-Phe(4-F)-OH; Fmoc-D-4-F-Phe; Fmoc-D-p-fluorophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-4-Fluorophe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support cGMP-compliant production for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.