Description

(S)-3-Amino-1-Hydroxy-3,4-Dihydroquinolin-2(1H)-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel therapeutic agents, particularly in the fields of oncology and neurology. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of proprietary drug candidates, particularly kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Used in asymmetric synthesis and medicinal chemistry research to construct complex heterocyclic scaffolds.
• Research & Development: Serves as a standard or reference compound in analytical method development and pharmacological studies.
• Process Chemistry: Employed in route scouting and scale-up activities for the production of Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	(S)-3-Amino-1-Hydroxy-3,4-Dihydroquinolin-2(1H)-One Hydrochloride
CAS No.	177943-33-8
Molecular Formula	C9H11N2O2·HCl
Molecular Weight	214.65 g/mol
Synonyms	(3S)-3-Amino-1-hydroxy-3,4-dihydro-2(1H)-quinolinone hydrochloride; (S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one HCl; 1H-Quinolin-2-one, 3-amino-3,4-dihydro-1-hydroxy-, hydrochloride, (3S)-; UNII-1W8I7188W0; 1W8I7188W0; (S)-AHQO hydrochloride; (S)-3-Amino-1-hydroxy-3,4-dihydro-2(1H)-quinolinone monohydrochloride
EINECS	Contact for details

Quality Control

Our (S)-3-Amino-1-Hydroxy-3,4-Dihydroquinolin-2(1H)-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent specifications suitable for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.