Description

Benzo[D]Oxazol-4-Yl Trifluoromethanesulfonate (Wxc08878) is a high-purity, specialized chemical intermediate featuring a reactive triflate leaving group. This compound is critical for facilitating advanced cross-coupling and nucleophilic substitution reactions in complex organic syntheses. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing benzoxazole or related fused heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic motifs for bioactivity.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport molecules.
• Cross-Coupling Reactions: The trifluoromethanesulfonate (triflate) group makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings to form new carbon-carbon bonds.
• Nucleophilic Substitution: Enables the introduction of various nucleophiles (amines, alkoxides) at the 4-position of the benzoxazole ring system under controlled conditions.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis or as a core structure in catalyst design for asymmetric synthesis.

Basic Information

Item	Details
Product Name	Benzo[D]Oxazol-4-Yl Trifluoromethanesulfonate (Wxc08878)
CAS No.	177734-80-4
Molecular Formula	C9H4F3NO4S
Molecular Weight	279.19 g/mol
Synonyms	4-Benzoxazolyl Triflate; 4-(Trifluoromethanesulfonyloxy)benzoxazole; Benzo[d]oxazol-4-yl trifluoromethanesulfonate; 4-Benzoxazolyl Trifluoromethanesulfonate; 1,3-Benzoxazol-4-yl trifluoromethanesulfonate; Trifluoromethanesulfonic acid benzo[d]oxazol-4-yl ester; WXC-08878; Wxc08878
EINECS	Contact for details

Quality Control

Every batch of Benzo[D]Oxazol-4-Yl Trifluoromethanesulfonate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR (¹H and ¹³C), and mass spectrometry to ensure identity and consistency. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.