Description

n-[[(1S,8Ar)-2,3,4,5,6,7,8,8A-Octahydro-1H-Quinolizin-1-Yl]Methyl]-4-Amino-5-Chloro-2-Methoxy-Benzamide is a high-purity, complex organic compound with a defined stereochemistry, serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its precise molecular architecture makes it valuable for constructing novel active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily targeted at research and development laboratories and production facilities in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug research.
• Chemical Biology Research: Used as a probe or precursor in studying enzyme inhibition and receptor-ligand interactions due to its quinolizine scaffold.
• Process Chemistry Development: Serves as a model compound for optimizing scalable synthetic routes and chiral separation techniques.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Custom Synthesis: A starting point for the custom synthesis of specialized derivatives and analogs for client-specific research programs.

Basic Information

Product Name	n-[[(1S,8Ar)-2,3,4,5,6,7,8,8A-Octahydro-1H-Quinolizin-1-Yl]Methyl]-4-Amino-5-Chloro-2-Methoxy-Benzamide
CAS No.	177187-62-1
Molecular Formula	C22H30ClN3O2
Molecular Weight	403.95 g/mol
Synonyms	4-Amino-5-chloro-2-methoxy-N-[[(1S,8aR)-decahydro-2-quinolyl]methyl]benzamide; (1S,8aR)-N-[(4-Amino-5-chloro-2-methoxybenzoyl)methyl]decahydroquinoline; 5-Chloro-4-amino-2-methoxy-N-[(1S,8aR)-octahydro-2-quinolylmethyl]benzamide; Benzamide, N-[[(1S,8aR)-decahydro-2-quinolyl]methyl]-4-amino-5-chloro-2-methoxy-; Decahydroquinoline benzamide derivative (CAS 177187-62-1)
EINECS	Contact for details

Quality Control

Our n-[[(1S,8Ar)-2,3,4,5,6,7,8,8A-Octahydro-1H-Quinolizin-1-Yl]Methyl]-4-Amino-5-Chloro-2-Methoxy-Benzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.