Description

Quinoline, 8-Bromo-2-(Trifluoromethyl)- CAS NO 176722-63-7 is a high-purity, halogenated quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring both bromine and trifluoromethyl substituents, makes it an exceptionally valuable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its electron-deficient quinoline core.
• Chemical Synthesis: Enables versatile cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) via the reactive bromine atom for further functionalization.
• Fluorine Chemistry: An important substrate for studying the effects of fluorine substitution on the physical and chemical properties of heteroaromatic systems.

Basic Information

Product Name	Quinoline, 8-Bromo-2-(Trifluoromethyl)-
CAS No.	176722-63-7
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	8-Bromo-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-8-bromoquinoline; 8-Bromo-2-trifluoromethylquinoline; Quinoline, 8-bromo-2-(trifluoromethyl)-; 176722-63-7; 8-Br-2-CF3-Quinoline
EINECS	Contact for details

Quality Control

Our production of 8-Bromo-2-(trifluoromethyl)quinoline adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.