Description

Fmoc-4-Aminomethyl-Phenylacetic Acid CAS NO 176504-01-1 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). It serves as a key building block for introducing the unnatural amino acid 4-aminomethyl-phenylacetic acid into peptide chains, enabling the creation of complex biomolecules with specific structural and functional properties. This compound is primarily utilized by pharmaceutical researchers, biotechnology companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation and Linker Chemistry: The aminomethyl-phenylacetic acid moiety can act as a spacer or linker for attaching peptides to other molecules, surfaces, or solid supports.
• Production of Peptidomimetics: Enables the incorporation of non-natural aromatic side chains to enhance peptide stability, bioavailability, and binding affinity.
• Biochemical Probe Development: Essential for creating labeled or modified peptides used in studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-4-Aminomethyl-Phenylacetic Acid
CAS No.	176504-01-1
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-4-(Aminomethyl)phenylacetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(aminomethyl)benzeneacetic acid; Fmoc-Ampa-OH; 4-[[(9-Fluorenylmethyloxy)carbonyl]aminomethyl]phenylacetic acid; N-Fmoc-4-aminomethylphenylacetic acid; Fmoc-AMPAA; (4-[[(9H-Fluoren-9-ylmethoxy)carbonylamino]methyl]phenyl)acetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-4-Aminomethyl-Phenylacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals used in pharmaceutical research, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.