Description

Spiro[Bicyclo[4.1.0]Heptane-7,1-Cyclopentan]-3-Ol, 2-Methyl-, [1-α-,6-α-,7-Ba-(2R*,3S*)]- (9Ci) is a complex, stereochemically defined spirocyclic compound that serves as a valuable chiral building block in advanced organic synthesis. Its unique fused ring structure and defined stereochemistry make it a critical intermediate for constructing molecules with specific three-dimensional architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries who require high-purity, structurally sophisticated intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the synthesis of advanced, stereoselective pesticides and herbicides where the specific spatial orientation of the molecule is crucial for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the development of novel chiral ligands and organocatalysts used in enantioselective synthesis.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties due to its rigid, polycyclic framework.
• Fragrance and Flavor Chemistry: Potential intermediate for synthesizing complex, musky, or woody odorants where the spirocyclic structure contributes to scent profile stability and longevity.
• Academic and Contract Research: Employed in university and CRO laboratories for methodological studies in synthetic organic chemistry, including cyclopropanation and spiroannulation reactions.

Basic Information

Item	Details
Product Name	Spiro[Bicyclo[4.1.0]Heptane-7,1-Cyclopentan]-3-Ol, 2-Methyl-, [1-α-,6-α-,7-Ba-(2R*,3S*)]- (9Ci)
CAS No.	176101-42-1
Molecular Formula	C12H18O
Molecular Weight	178.27 g/mol
Synonyms	2-Methylspiro[bicyclo[4.1.0]heptane-7,1'-cyclopentan]-3-ol; (1R,2S,6R,7S)-2-Methylspiro[bicyclo[4.1.0]heptane-7,1'-cyclopentan]-3-ol; 2-Methylspiro(bicyclo[4.1.0]heptane-7,1'-cyclopentan)-3-ol; Spiro[bicyclo[4.1.0]heptane-7,1'-cyclopentan]-3-ol, 2-methyl-, (1α,2β,6α,7β)-rel-; 176101-42-1; Spirocyclic alcohol intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor quality documentation to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.