Description

tert-Butyl 2-(Bromomethyl)-1H-Benzo[D]Imidazole-1-Carboxylate is a high-value, protected benzimidazole derivative featuring a reactive bromomethyl handle, making it a versatile and critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functionalized benzimidazole motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors, antiviral agents, and receptor modulators that incorporate the benzimidazole pharmacophore.
• Agrochemical Synthesis: Used in the research and development of new fungicides, herbicides, and plant growth regulators where the benzimidazole core provides biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs) due to its functionalizable aromatic system.
• Peptidomimetics and Bio-conjugation: The reactive bromomethyl group allows for alkylation of nucleophiles like amines and thiols, facilitating the creation of peptide mimics or linker molecules for bioconjugation.
• Custom Chemical Synthesis: Provides a protected, reactive scaffold for contract research organizations (CROs) and custom synthesis houses to build bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 2-(Bromomethyl)-1H-Benzo[D]Imidazole-1-Carboxylate
CAS No.	175531-13-2
Molecular Formula	C14H17BrN2O2
Molecular Weight	325.20 g/mol
Synonyms	1-Boc-2-(bromomethyl)benzimidazole; 2-(Bromomethyl)-1H-benzimidazole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-(bromomethyl)-1H-benzo[d]imidazole-1-carboxylate; 1-(tert-Butoxycarbonyl)-2-(bromomethyl)benzimidazole; 1-Boc-2-bromomethylbenzimidazole; 2-Bromomethyl-1-Boc-benzimidazole; 175531-13-2; 1H-Benzo[d]imidazole-1-carboxylic acid, 2-(bromomethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Bromomethyl)-1H-Benzo[D]Imidazole-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive analytical data including HPLC purity, NMR (1H & 13C), and mass spectrometry for identity and quality verification. Certificates of Analysis (COA) detailing all specifications are available for every batch and provided upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.