Description

Ethyl 4-Hydroxy-8-(Trifluoromethoxy)Quinoline-3-Carboxylate is a high-value, multifunctional quinoline derivative characterized by its trifluoromethoxy and ester functional groups. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used as a building block for developing new generation pesticides and herbicides, leveraging the biological activity of the quinoline scaffold.
• Material Science: Serves as a monomer or functional additive in the development of specialty polymers, coatings, and electronic materials due to its aromatic and fluorinated structure.
• Chemical Synthesis: Acts as a versatile synthon for further chemical transformations, including hydrolysis, amidation, and cross-coupling reactions to create diverse chemical libraries.
• Fluorine Chemistry: The trifluoromethoxy group makes it a valuable compound for research in fluorine chemistry, exploring its effects on lipophilicity, metabolic stability, and bioavailability.

Basic Information

Item	Details
Product Name	Ethyl 4-Hydroxy-8-(Trifluoromethoxy)Quinoline-3-Carboxylate
CAS No.	175278-35-0
Molecular Formula	C13H10F3NO4
Molecular Weight	301.22 g/mol
Synonyms	Ethyl 4-hydroxy-8-(trifluoromethoxy)quinoline-3-carboxylate; 8-(Trifluoromethoxy)-4-hydroxyquinoline-3-carboxylic acid ethyl ester; 4-Hydroxy-8-trifluoromethoxy-quinoline-3-carboxylic acid ethyl ester; Quinoline-3-carboxylic acid, 4-hydroxy-8-(trifluoromethoxy)-, ethyl ester; CAS 175278-35-0
EINECS	Contact for details

Quality Control

Our Ethyl 4-Hydroxy-8-(Trifluoromethoxy)Quinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurities, and full spectral data. Our quality commitment aligns with cGMP and ISO 9001 standards where applicable for intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.