Description

6-(2,2,2-Trifluoroethoxy)Nicotinic Acid is a high-value fluorinated nicotinic acid derivative, serving as a critical building block in advanced organic synthesis. Its primary commercial value lies in its role as a key intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate the unique properties of the trifluoroethoxy moiety into their molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the trifluoroethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and functional materials with specific fluorinated properties.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study biological systems and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A key requested intermediate for custom synthesis projects and scale-up services for clients in life sciences.

Basic Information

Product Name	6-(2,2,2-Trifluoroethoxy)Nicotinic Acid
CAS No.	175204-90-7
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	6-(2,2,2-Trifluoroethoxy)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-(2,2,2-trifluoroethoxy)-; Nicotinic acid, 6-(2,2,2-trifluoroethoxy)-; 6-(Trifluoroethoxy)nicotinic acid; 2,2,2-Trifluoroethyl 6-nicotinate (precursor related); 5-Carboxy-2-(2,2,2-trifluoroethoxy)pyridine
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoroethoxy)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.