Description

6-(Trifluoromethoxy)-4-Quinolinol is a high-purity, fluorinated quinoline derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and valuable building block for the development of novel pharmaceuticals and agrochemicals, where the trifluoromethoxy group imparts unique metabolic stability and lipophilicity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and antimicrobial programs.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorinated moiety enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing organic electronic materials, ligands for catalysis, and fluorescent probes.
• Chemical Biology: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	6-(Trifluoromethoxy)-4-Quinolinol
CAS No.	175203-87-9
Molecular Formula	C₁₀H₆F₃NO₂
Molecular Weight	229.16 g/mol
Synonyms	4-Hydroxy-6-(trifluoromethoxy)quinoline; 6-(Trifluoromethoxy)quinolin-4-ol; 4-Quinolinol, 6-(trifluoromethoxy)-; 6-Trifluoromethoxy-4-hydroxyquinoline; Quinolin-4-ol, 6-(trifluoromethoxy)-; 6-(Trifluoromethoxy)-4-hydroxyquinoline; 175203-87-9
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethoxy)-4-Quinolinol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. For projects requiring regulatory support, we can supply documentation aligned with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.