Description

4-Hydroxy-6-(Trifluoromethoxy)Quinoline-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block and intermediate of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring a quinoline core substituted with a carboxylic acid, a hydroxyl group, and a trifluoromethoxy moiety, makes it a critical precursor for the development of novel active compounds. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research for anti-infective, anti-inflammatory, and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Serves as a sophisticated precursor in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline scaffold and the metabolic stability imparted by the trifluoromethoxy group.
• Material Science: Used in the research and synthesis of advanced organic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic electronic devices.
• Chemical Synthesis: Functions as a versatile intermediate in organic chemistry for constructing complex heterocyclic systems, enabling medicinal and process chemistry research.
• Biochemical Tool Compound: Potential use in biochemical assays and as a probe in life science research to study enzyme inhibition or receptor binding.

Basic Information

Item	Detail
Product Name	4-Hydroxy-6-(Trifluoromethoxy)Quinoline-3-Carboxylic Acid
CAS No.	175203-86-8
Molecular Formula	C₁₁H₆F₃NO₄
Molecular Weight	273.17 g/mol
Synonyms	6-(Trifluoromethoxy)-4-hydroxyquinoline-3-carboxylic acid; 4-Hydroxy-6-(trifluoromethoxy)-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 4-hydroxy-6-(trifluoromethoxy)-; 175203-86-8; 4-Hydroxy-6-trifluoromethoxyquinoline-3-carboxylic acid; 6-Trifluoromethoxy-4-hydroxyquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-6-(Trifluoromethoxy)Quinoline-3-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements for specific research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.