Description

4-Chloro-6-Methyl-5-Nitro-2-(Trifluoromethyl)Quinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the strategic combination of reactive functional groups—chloro, nitro, and trifluoromethyl—on a quinoline scaffold, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require sophisticated intermediates for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting infectious diseases or cancer, leveraging the quinoline core's biological relevance.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl and nitro groups can enhance bioactivity and environmental stability.
• Material Science: Acts as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport layers.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactive chlorine substituent, allowing for the introduction of diverse aryl and heteroaryl groups.
• Fluorine Chemistry: The presence of the trifluoromethyl group makes it a valuable scaffold for studying the effects of fluorine incorporation on the physicochemical properties of molecules.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized quinoline-based dyes and colorants for niche industrial applications.

Basic Information

Product Name	4-Chloro-6-Methyl-5-Nitro-2-(Trifluoromethyl)Quinoline
CAS No.	175203-61-9
Molecular Formula	C₁₁H₆ClF₃N₂O₂
Molecular Weight	290.62 g/mol
Synonyms	4-Chloro-6-methyl-5-nitro-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-4-chloro-6-methyl-5-nitroquinoline; 5-Nitro-4-chloro-6-methyl-2-trifluoromethylquinoline; Quinoline, 4-chloro-6-methyl-5-nitro-2-(trifluoromethyl)-; 175203-61-9; 4-Chloro-6-methyl-5-nitro-2-trifluoromethylquinoline; 2-Trifluoromethyl-4-chloro-6-methyl-5-nitroquinoline
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-6-Methyl-5-Nitro-2-(Trifluoromethyl)Quinoline adheres to a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and GC for residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.