Description

n-[3,5-Bis(Trifluoromethyl)Benzenesulphonyl]-L-Methionyl Hydrazide is a specialized, high-purity chemical building block featuring a unique trifluoromethylated benzenesulfonyl group linked to a methionine-derived hydrazide. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents, particularly in the development of protease inhibitors and other targeted therapeutics. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for its precise structural motifs that enable the creation of novel drug candidates with enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel protease inhibitors and other small-molecule drug candidates.
• Bioconjugation & Probe Development: Used in research for creating chemical probes and affinity labels due to its reactive hydrazide group and fluorinated aromatic system.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Peptidomimetic Synthesis: Employed in the construction of peptidomimetics where the methionine and sulfonamide groups mimic peptide bonds and confer specific bioactivity.
• Chemical Biology Tool: Utilized in the development of activity-based protein profiling (ABPP) reagents.
• High-Value Agrochemical Intermediate: Potential use in the synthesis of advanced, fluorinated active ingredients for crop protection.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Benzenesulphonyl]-L-Methionyl Hydrazide
CAS No.	175202-22-9
Molecular Formula	C14H15F6N3O3S2
Molecular Weight	451.41 g/mol
Synonyms	L-Methionine, N-[3,5-bis(trifluoromethyl)benzenesulfonyl]-, hydrazide; 3,5-Bis(trifluoromethyl)benzenesulfonyl-L-methionine hydrazide; BTFMBS-Met-NHNH2; N-(3,5-Bis(trifluoromethyl)phenylsulfonyl)-L-methionyl hydrazide; 175202-22-9; Methionyl hydrazide, N-[3,5-bis(trifluoromethyl)benzenesulfonyl]-; (2S)-2-[[[3,5-Bis(trifluoromethyl)phenyl]sulfonyl]amino]-4-(methylsulfanyl)butanehydrazide
EINECS	Contact for details

Quality Control

Our n-[3,5-Bis(Trifluoromethyl)Benzenesulphonyl]-L-Methionyl Hydrazide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.