Description

Ethyl 6-Chloro-1,4-Dihydro-8-Methyl-4-Oxoquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the quinolone carboxylic acid ester class. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting bacterial infections, offering a key building block for research and commercial-scale production. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in antibiotic development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of novel fluoroquinolone and quinolone antibiotic APIs.
• Antibacterial Drug Research: Serves as a core scaffold in medicinal chemistry for developing new antibacterial agents with improved efficacy and spectrum.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale synthesis for new drug candidates.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & Institutional Research: Utilized in universities and research institutes for studying structure-activity relationships (SAR) of quinolone derivatives.

Basic Information

Product Name	Ethyl 6-Chloro-1,4-Dihydro-8-Methyl-4-Oxoquinoline-3-Carboxylate
CAS No.	175134-96-0
Molecular Formula	C₁₃H₁₂ClNO₃
Molecular Weight	265.69 g/mol
Synonyms	Ethyl 6-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate; 6-Chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester; 6-Chloro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acid Ethyl Ester; 3-Quinolinecarboxylic acid, 6-chloro-1,4-dihydro-8-methyl-4-oxo-, ethyl ester; 6-Chloro-8-methyl-4-oxo-1H-quinoline-3-carboxylic acid ethyl ester; Ethyl 6-chloro-8-methyl-4-oxo-1H-quinoline-3-carboxylate; 175134-96-0
EINECS	Contact for details

Quality Control

Our Ethyl 6-Chloro-1,4-Dihydro-8-Methyl-4-Oxoquinoline-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.