Description

(S)-6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Yl-Amine Hcl is a high-purity chiral amine building block, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its value lies in its defined stereochemistry and fluorine substitution, which are critical for modulating the biological activity, metabolic stability, and pharmacokinetic properties of target molecules. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, particularly those focused on central nervous system (CNS) and cardiovascular drug discovery.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in neurological and psychiatric therapeutic areas.
• Agrochemical Research: Serves as a building block for creating new crop protection agents and herbicides with enhanced efficacy.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical transformations.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship exploration by providing a fluorinated, conformationally constrained amine scaffold.
• Process Chemistry & Scale-Up: Supplied in consistent quality for pilot plant and commercial manufacturing of target molecules.
• Reference Standard: Suitable for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	(S)-6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Yl-Amine Hydrochloride
CAS No.	173996-44-6
Molecular Formula	C₁₀H₁₃ClFN
Molecular Weight	201.67 g/mol
Synonyms	(2S)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; (S)-6-Fluoro-2-aminotetralin HCl; (S)-6-Fluoro-2-Tetralylamine Hydrochloride; (S)-6-Fluoro-1,2,3,4-tetrahydro-2-naphthylamine hydrochloride; (S)-2-Amino-6-fluorotetralin hydrochloride; 6-Fluoro-(S)-2-aminotetralin HCl; (S)-AT6-F HCl; FNT-Amine (S)-isomer HCl
EINECS	Contact for details

Quality Control

Every batch of (S)-6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Yl-Amine Hcl is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity compliant with industry standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request and are essential for your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.