Description

5-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Ylamine Hydrochloride is a high-purity fluorinated tetralin derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in providing a structurally rigid, fluorine-containing amine scaffold essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of central nervous system (CNS) agents, receptor modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the fluorine atom and tetralin structure enhance activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tagging reagent in biochemical research and drug discovery platforms.
• Material Science Research: Investigated as a monomer or functional additive for the synthesis of specialty polymers with unique optical or electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target compounds on various scales.

Basic Information

Product Name	5-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Ylamine Hydrochloride
CAS No.	173996-43-5
Molecular Formula	C₁₀H₁₃ClFN
Molecular Weight	201.67 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; 2-Amino-5-fluoro-1,2,3,4-tetrahydronaphthalene hydrochloride; 5-Fluoro-2-tetralinamine hydrochloride; (5-Fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amine hydrochloride; 5-Fluoro-2-aminotetralin HCl; 173996-43-5; 5-Fluoro-2-THN HCl; 5-F-THN-amine HCl
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.