Description

Spiro[1,2,4-Trihydroisoquinoline-1,4-Piperidine]-3-One Hcl Salt is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily sought by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting neurological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up API synthesis under GMP conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic Research: Utilized in chemical and pharmacological research to explore new synthetic methodologies and biological activities.

Basic Information

Product Name	Spiro[1,2,4-Trihydroisoquinoline-1,4-Piperidine]-3-One Hcl Salt
CAS No.	173944-49-5
Molecular Formula	C12H14N2O • HCl
Molecular Weight	238.71 g/mol
Synonyms	Spiro[1,2,4-trihydroisoquinoline-1,4'-piperidin]-3-one hydrochloride; 1',2',3',4'-Tetrahydrospiro[piperidine-4,1'-isoquinolin]-3-one hydrochloride; 3-Oxo-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidine] hydrochloride; Spiro[isoquinoline-1(2H),4'-piperidin]-3-one hydrochloride; Tetrahydrospiro[isoquinoline-1,4'-piperidin]-3-one HCl
EINECS	Contact for details

Quality Control

Our Spiro[1,2,4-Trihydroisoquinoline-1,4-Piperidine]-3-One Hcl Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.