Description

5-Methylspiro[1,3-Dihydroisobenzofuran-3,4'-Piperidine] Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and neuropharmacological research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and manufacturing who require reliable, high-quality intermediates for scale-up and production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for CNS disorders.
• Process Chemistry & Scale-Up: Serves as a critical raw material for the development and commercial manufacturing of APIs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development.

Basic Information

Product Name	5-Methylspiro[1,3-Dihydroisobenzofuran-3,4'-Piperidine] Hydrochloride
CAS No.	173943-99-2
Molecular Formula	C14H19NO·HCl
Molecular Weight	253.77 g/mol
Synonyms	5-Methylspiro[isobenzofuran-1(3H),4'-piperidine] hydrochloride; 1',3'-Dihydro-5-methylspiro[isobenzofuran-1,4'-piperidine] hydrochloride; 5-Methyl-1',3'-dihydrospiro[isobenzofuran-1,4'-piperidine] hydrochloride; 5-Methylspiro[1,3-dihydro-2-benzofuran-3,4'-piperidine] hydrochloride; 173943-99-2; 5-Methylspiro(Dihydroisobenzofuran)Piperidine HCl
EINECS	Contact for details

Quality Control

Our 5-Methylspiro[1,3-Dihydroisobenzofuran-3,4'-Piperidine] Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.