Description

(S,S)-2,6-Bis(4-Isopropyl-2-Oxazolin-2-Yl)Pyridine is a high-purity, chiral ligand belonging to the bis(oxazoline) class, known for its C2-symmetric structure. This compound is a critical component for enabling highly enantioselective transformations in asymmetric catalysis, offering superior control over stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise chiral induction in metal-catalyzed reactions such as cyclopropanations, Diels-Alder reactions, and various C-H functionalizations.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for copper(I), iron(II), and other transition metals in enantioselective synthesis.
• Pharmaceutical Intermediate Synthesis: For the production of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Agrochemical Development: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: As a building block for chiral metal-organic frameworks (MOFs) or polymeric catalysts.
• Academic & Process R&D: A key reagent for developing new catalytic methodologies and scaling up asymmetric processes.
• Fine Chemical Production: For manufacturing specialty flavors, fragrances, and electronic chemicals with specific chiral configurations.

Basic Information

Item	Details
Product Name	(S,S)-2,6-Bis(4-Isopropyl-2-Oxazolin-2-Yl)Pyridine
CAS No.	173829-03-3
Molecular Formula	C17H23N3O2
Molecular Weight	301.39 g/mol
Synonyms	(S,S)-2,6-Bis[(4S)-4-isopropyl-4,5-dihydro-2-oxazolyl]pyridine; (S,S)-Bis(4-isopropyl-2-oxazolinyl)pyridine; (S,S)-PyBOX(i-Pr); (S,S)-2,6-Bis(4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine; (S,S)-2,6-Bis[4-(1-methylethyl)-2-oxazolin-2-yl]pyridine; (S,S)-iPr-PyBOX; Chiral Pyridine Bis(oxazoline) Ligand
EINECS	Contact for details

Quality Control

Every batch of (S,S)-2,6-Bis(4-Isopropyl-2-Oxazolin-2-Yl)Pyridine is produced and tested under strict quality management systems to ensure high chiral purity and chemical consistency. Our standard quality protocol includes comprehensive analysis by HPLC, NMR, and optical rotation to confirm identity, assay, and enantiomeric excess. A Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and chiral integrity. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Specific Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.