Description

Methyl 2-Diazo-3,3,3-Trifluoro-Propionate is a highly reactive diazo compound and a versatile trifluoromethylated building block. It is a critical intermediate for the synthesis of complex fluorinated molecules, prized for its ability to introduce the trifluoromethyl group and a reactive diazo functionality in a single step. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialized fluorinated synthons.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer drug discovery.
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials with unique surface properties.
• Organic Synthesis Reagent: Employed in cyclopropanation reactions, X-H insertion reactions (C-H, O-H, N-H), and as a carbene precursor in catalytic cycles.
• Fluorine Chemistry Research: A fundamental reagent for academic and industrial R&D focused on exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	Methyl 2-Diazo-3,3,3-Trifluoro-Propionate
CAS No.	173558-71-9
Molecular Formula	C5H3F3N2O2
Molecular Weight	180.08 g/mol
Synonyms	Methyl 2-Diazo-3,3,3-Trifluoropropanoate; Methyl 2-Diazo-3,3,3-Trifluoropropionate; 2-Diazo-3,3,3-Trifluoropropionic Acid Methyl Ester; Methyl 2-Diazo-3,3,3-Trifluoro-2-Propionate; Trifluoromethyl Diazoacetate Methyl Ester; Methyl Trifluoromethyl Diazoacetate; Methyl α-Diazo-β,β,β-Trifluoropropionate; Methyl 2-Diazo-4,4,4-Trifluoro-Butyrate (common misnomer)
EINECS	Contact for details

Quality Control

Our Methyl 2-Diazo-3,3,3-Trifluoro-Propionate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity, NMR, and GC-MS characterization. A Certificate of Analysis (COA) detailing all specifications is available with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to minimize decomposition and volatility. Due to its light-sensitive and easily oxidized nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.