Description

1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, Tris(1,1-Dimethylethyl) Ester, Monohydrochloride is a key protected intermediate in the synthesis of sophisticated macrocyclic chelating agents. This compound is critically important for the development of advanced contrast agents used in medical imaging, such as MRI, due to its ability to form stable complexes with gadolinium and other lanthanide ions. It is primarily required by pharmaceutical R&D laboratories, diagnostic imaging companies, and fine chemical manufacturers engaged in producing high-value, metal-based therapeutics and diagnostics.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its monoamide derivatives.
• MRI Contrast Agent Precursor: Used in the manufacture of gadolinium-based contrast agents (GBCAs) like Gadoterate meglumine, essential for magnetic resonance imaging.
• Radiopharmaceutical Development: Serves as a chelator scaffold for labeling peptides and antibodies with diagnostic or therapeutic radionuclides (e.g., Lu-177, Y-90, Ga-68).
• Research Chemical: Employed in academic and industrial research for studying metal-ligand coordination chemistry and developing new imaging probes.
• Fine Chemical Synthesis: Used in multi-step organic syntheses requiring a protected, multifunctional azamacrocycle.
• Catalyst Ligand Synthesis: Acts as a precursor for creating specialized ligands used in homogeneous catalysis.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, Tris(1,1-Dimethylethyl) Ester, Monohydrochloride
CAS No.	173526-92-6
Molecular Formula	C30H57N4O6 • HCl
Molecular Weight	597.27 g/mol (free base: 560.80)
Synonyms	DO3A-tris(t-butyl ester) hydrochloride; 1,4,7-Tris(carboxymethyl)-10-(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate hydrochloride; Tris-tert-butyl DO3A hydrochloride; H3DO3A(t-Bu)3•HCl; 2,2',2''-(10-(tert-Butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid tris(1,1-dimethylethyl) ester hydrochloride; Protected DO3A hydrochloride; tert-Butyl DO3A ester HCl
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.