Description

N,n-Di-T-Boc-(2-Fluoro-4-Nitrophenyl)Methanamine is a specialized Boc-protected amine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected primary amine functionality that is stable to a wide range of reaction conditions, enabling the precise construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) and solution-phase synthesis where a protected amine is required.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs.
• Agrochemical Synthesis: Intermediate in the development of advanced herbicides, fungicides, and pesticides.
• Material Science: Precursor for functionalized polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	N,n-Di-T-Boc-(2-Fluoro-4-Nitrophenyl)Methanamine
CAS No.	172349-08-5
Molecular Formula	C₂₁H₃₁FN₂O₆
Molecular Weight	426.48 g/mol
Synonyms	1,1-Dimethylethyl N-[[(1,1-dimethylethoxy)carbonyl][(2-fluoro-4-nitrophenyl)methyl]amino]carbamate; Bis(tert-butoxycarbonyl)-(2-fluoro-4-nitrobenzyl)amine; Di-Boc-(2-fluoro-4-nitrobenzyl)amine; N,N-Bis(tert-butoxycarbonyl)-1-(2-fluoro-4-nitrophenyl)methanamine; N,N-Di-Boc-2-fluoro-4-nitrobenzylamine; (2-Fluoro-4-nitrobenzyl)bis(tert-butoxycarbonyl)amine; tert-Butyl N-[(tert-butoxycarbonyl)[(2-fluoro-4-nitrophenyl)methyl]amino]carbamate
EINECS	Contact for details

Quality Control

Our N,n-Di-T-Boc-(2-Fluoro-4-Nitrophenyl)Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring high-purity intermediates, from research to commercial-scale cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.