Description

(R)-6,6'-Dimethyl-1,1'-Bi-2-Naphthol CAS NO 172170-94-4 is a high-purity, axially chiral binaphthol derivative widely utilized as a privileged ligand and catalyst in asymmetric synthesis. Its core value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer pharmaceuticals and fine chemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance chiral auxiliaries.

Application

• Asymmetric Catalysis: Serves as a key chiral ligand for transition metal complexes (e.g., with Ti, B, Al) in enantioselective C-C bond formation, oxidation, and reduction reactions.
• Pharmaceutical Intermediates: Critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in complex multi-step syntheses.
• Chiral Resolution: Used to prepare chiral stationary phases for HPLC or as a resolving agent for the separation of racemic mixtures.
• Organocatalysis: Functions as a chiral Brønsted acid catalyst or as a precursor for other organocatalysts in stereoselective reactions.
• Material Science: Employed in the development of chiral polymers, liquid crystals, and molecular recognition systems.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A fundamental tool for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	(R)-6,6'-Dimethyl-1,1'-Bi-2-Naphthol
CAS No.	172170-94-4
Molecular Formula	C22H18O2
Molecular Weight	314.38 g/mol
Synonyms	(R)-6,6'-Dimethyl-1,1'-binaphthyl-2,2'-diol; (R)-6,6'-Dimethyl-BINOL; (R)-(-)-6,6'-Dimethyl-2,2'-dihydroxy-1,1'-binaphthyl; (R)-(-)-6,6'-Dimethyl-1,1'-bi-2-naphthol; (R)-DM-BINOL; (R)-6,6'-Dimethyl-[1,1'-binaphthalene]-2,2'-diol; (R)-(-)-6,6'-Dimethyl-1,1'-binaphthyl-2,2'-diol; (R)-6,6'-Dimethyl-1,1'-binaphthalene-2,2'-diol
EINECS	Contact for details

Quality Control

Our (R)-6,6'-Dimethyl-1,1'-Bi-2-Naphthol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination and standard purity assays. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	205 - 210 °C
Specific Rotation	-35° to -39° (c=1 in THF)
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.