Description

Doyle Dirhodium Catalyst-Rh2(4S-Mppim)4 is a highly specialized, chiral dirhodium(II) carboxylate complex designed for asymmetric synthesis. This catalyst matters because it enables highly enantioselective C-H functionalization and cyclopropanation reactions, which are critical for constructing complex chiral molecules with high precision. Pharmaceutical, agrochemical, and fine chemical R&D laboratories need it to develop novel active ingredients and advanced intermediates where stereochemical control is paramount.

Application

• Asymmetric C-H Amination: For the enantioselective insertion of nitrenes into C-H bonds to create chiral amines.
• Enantioselective Cyclopropanation: A key catalyst for the synthesis of chiral cyclopropane rings, important structural motifs in bioactive compounds.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of chiral active pharmaceutical ingredients (APIs).
• Agrochemical Product Development: For creating enantiomerically pure herbicides, fungicides, and insecticides.
• Methodology Development in Academia: A valuable tool for organic chemists exploring new asymmetric transformations.
• Fine Chemical Manufacturing: Applied in pilot-scale and small-batch production of high-value, chiral specialty chemicals.

Basic Information

Product Name	Doyle Dirhodium Catalyst-Rh2(4S-Mppim)4
CAS No.	171230-55-0
Molecular Formula	C₇₂H₈₀N₈O₈Rh₂
Molecular Weight	1388.27 g/mol
Synonyms	Dirhodium(II) tetrakis[(4S)-(-)-1-(2-methylpropyl)-2-imidazolidinylmethyl acetate]; Rh₂(S-MPTIM)₄; Doyle Catalyst; Dirhodium(II) (S)-N-(2-Methylpropyl)-2-imidazolidinylmethylacetate Tetramer; Chiral Dirhodium(II) Carboxylate Catalyst; Rh₂(4S-MPPIM)₄; Asymmetric Dirhodium Catalyst
EINECS	Contact for details

Quality Control

Every batch of our Doyle Dirhodium Catalyst is manufactured and tested under strict quality management protocols to ensure consistent, high-performance material for critical asymmetric synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as enantiomeric purity, rhodium content, and spectroscopic identity. Our quality systems support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain optimal catalytic activity.

Specification

Item	Specification
Appearance	Dark green to blue-green solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Rhodium Content	Contact for details
Specific Rotation	Contact for details
Solubility	Soluble in chlorinated and aromatic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.