Description

4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Benzohydrazide Hydrochloride is a high-purity chemical building block featuring a maleimide hydrazide hydrochloride structure, making it a critical intermediate for advanced synthesis. Its core value lies in enabling the precise and stable conjugation of bioactive molecules, which is essential for developing targeted therapeutics and diagnostic agents. This compound is primarily needed by pharmaceutical R&D teams, bioconjugation specialists, and manufacturers of active pharmaceutical ingredients (APIs) for applications in antibody-drug conjugates (ADCs) and other sophisticated drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Bioconjugation & Protein Labeling: The maleimide group selectively reacts with thiols (cysteine residues) under mild conditions, enabling site-specific modification of proteins, peptides, and antibodies with labels, drugs, or polymers.
• Polymer & Biomaterial Functionalization: Used to introduce reactive handles onto polymer backbones or hydrogel matrices for creating smart, responsive biomaterials.
• Small Molecule Prodrug Development: Acts as a versatile connector in the design of prodrugs, facilitating targeted release of active drug molecules at disease sites.
• Diagnostic Reagent Manufacturing: Employed in the production of contrast agents and molecular imaging probes by conjugating targeting moieties to reporter molecules.
• Research & Development: A valuable tool in academic and industrial research for exploring new bioconjugation strategies and novel therapeutic modalities.

Basic Information

Product Name	4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Benzohydrazide Hydrochloride
CAS No.	170966-09-3
Molecular Formula	C11H10N3O3 • HCl
Molecular Weight	267.67 g/mol (Free base: 231.21 g/mol)
Synonyms	4-(2,5-Dioxopyrrol-1-yl)benzohydrazide hydrochloride; 1-(4-Hydrazinylcarbonylphenyl)-1H-pyrrole-2,5-dione hydrochloride; Maleimidobenzoyl hydrazide hydrochloride; MBH-HCl; 4-Maleimidobenzoic hydrazide hydrochloride; p-Maleimidobenzoyl hydrazide HCl; 4-(Maleimid-1-yl)benzohydrazide hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Benzohydrazide Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.