Description

1,4,7,10-Tetraazacyclododecane-1-Acetic Acid is a high-purity, functionalized macrocyclic chelating agent, also known as a DOTA derivative. This compound is critically important for its exceptional ability to form stable complexes with a wide range of metal ions, particularly lanthanides and radiometals. It is an essential intermediate and building block for researchers and manufacturers in the pharmaceutical and diagnostic imaging sectors, enabling the development of advanced contrast agents and targeted radiopharmaceuticals. The CAS number for this compound is 170454-90-7.

Application

• Radiopharmaceutical Precursor: A key starting material for synthesizing DOTA-based chelators used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging agents.
• Contrast Agent Synthesis: Used in the production of Gadolinium(III) complexes for Magnetic Resonance Imaging (MRI) contrast enhancement.
• Therapeutic Radiopharmaceuticals: Serves as a bifunctional chelator for attaching therapeutic radioisotopes (e.g., Lutetium-177, Yttrium-90) to targeting vectors like peptides and antibodies.
• Chemical Research & Development: A versatile ligand in coordination chemistry for studying metal-ligand interactions and developing new metal-organic frameworks (MOFs) or catalysts.
• Diagnostic Kit Formulation: Incorporated into kits for the convenient, on-site preparation of radiolabeled diagnostic compounds.
• Bioconjugation Studies: The carboxylic acid group allows for covalent conjugation to biomolecules, facilitating the creation of targeted imaging and therapeutic probes.

Basic Information

Item	Detail
Product Name	1,4,7,10-Tetraazacyclododecane-1-Acetic Acid
CAS No.	170454-90-7
Molecular Formula	C12H24N4O2
Molecular Weight	256.35 g/mol
Synonyms	DOTA-AA; 1,4,7,10-Tetraazacyclododecane-1-acetic acid; 2-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid (common mis-assignment for related compound); 1-Carboxymethyl-1,4,7,10-tetraazacyclododecane; AAZTA precursor; Cyclen-1-acetic acid; 1,4,7,10-Tetraazacyclododecane-1-yl-acetic acid; DO1A
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1-Acetic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and production needs in compliance with cGMP and ISO 9001 standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from absorbed moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.