Description

L-Isoleucine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (S)- (9Ci) is a specialized, high-purity derivative of the essential amino acid L-Isoleucine, designed for advanced chemical synthesis and research. This compound serves as a critical protected amino acid building block, enabling the precise construction of complex peptides and bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in peptide chemistry and medicinal chemistry projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative to control regioselectivity and prevent side reactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to modify peptide backbones and develop compounds with enhanced biological activity or stability.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies and proteomics research.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialized amino acid analogs, flavors, and fragrances.

Basic Information

Product Name	L-Isoleucine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (S)- (9Ci)
CAS No.	169453-09-2
Molecular Formula	C14H28N2O3
Molecular Weight	272.39 g/mol
Synonyms	Boc-L-Isoleucine Methyl Ester; (S)-Methyl 2-((tert-Butoxycarbonyl)amino)-3-methylpentanoate; N-Boc-L-Isoleucine Methyl Ester; N-(tert-Butoxycarbonyl)-L-isoleucine Methyl Ester; Boc-Ile-OMe; Boc-L-Ile-OMe; L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Methyl N-Boc-L-isoleucinate
EINECS	Contact for details

Quality Control

Our production of this amino acid derivative adheres to stringent quality protocols. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide full traceability and detailed Certificates of Analysis (COA) upon request, ensuring compliance with the exacting standards required for pharmaceutical research and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.