Description

4-(3-Bromophenylamino)Quinazoline-6,7-Diol CAS NO 169205-86-1 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. Its core value lies in its role as a critical building block for the synthesis of targeted kinase inhibitors and other biologically active molecules. This compound is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel tyrosine kinase inhibitors (TKIs) and other small-molecule therapeutic agents.
• Oncology Research: Used in the development of targeted cancer therapies, particularly those aimed at epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) pathways.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Employed as a reference standard or tool compound in enzymatic assays and biological screening.
• Process Development: Used for scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value compounds for clinical trials.

Basic Information

Product Name	4-(3-Bromophenylamino)Quinazoline-6,7-Diol
CAS No.	169205-86-1
Molecular Formula	C14H10BrN3O2
Molecular Weight	332.15 g/mol
Synonyms	4-[(3-Bromophenyl)amino]-6,7-dihydroxyquinazoline; 6,7-Dihydroxy-4-[(3-bromophenyl)amino]quinazoline; 4-(3-Bromoanilino)-6,7-dihydroxyquinazoline; 4-(3-Bromophenylamino)-6,7-quinazolinediol; 169205-86-1; 4-(m-Bromophenylamino)quinazoline-6,7-diol
EINECS	Contact for details

Quality Control

Our 4-(3-Bromophenylamino)Quinazoline-6,7-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.