Description

(9R)-6'-Cinchonan-9-Amine Trihydrochloride is a high-purity chiral amine derivative of cinchona alkaloids, primarily used as a sophisticated catalyst and resolving agent. Its value lies in enabling highly enantioselective transformations, which are critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and process development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance chiral auxiliaries.

Application

• As a chiral phase-transfer catalyst (PTC) for asymmetric alkylation and other C-C bond-forming reactions.
• As a key ligand or organocatalyst in the synthesis of enantiomerically pure pharmaceutical intermediates.
• For the resolution of racemic mixtures of carboxylic acids and other acidic compounds via diastereomeric salt formation.
• In academic and industrial R&D for developing new asymmetric synthetic methodologies.
• As a precursor for synthesizing modified cinchona alkaloid derivatives with tailored catalytic properties.
• Potential use in the preparation of chiral stationary phases (CSPs) for analytical and preparative chromatography.

Basic Information

Product Name	(9R)-6'-Cinchonan-9-Amine Trihydrochloride
CAS No.	168960-94-9
Molecular Formula	C19H24N2·3HCl
Molecular Weight	~397.78 g/mol (Free base: 280.41)
Synonyms	(9R)-6'-Cinchonan-9-amine hydrochloride (1:3); (9R)-9-Amino-10,11-dihydro-6'-methoxycinchonan Trihydrochloride; (R)-9-Amino-10,11-dihydro-6'-methoxycinchonan Trihydrochloride; (R)-9-Aminocinchonan Trihydrochloride; (R)-9-Amino-6'-methoxycinchonan Trihydrochloride; Dihydroquinidine-9-amine Trihydrochloride; A Chiral Cinchona Alkaloid-Derived Amine Salt
EINECS	Contact for details

Quality Control

Our (9R)-6'-Cinchonan-9-Amine Trihydrochloride is produced and tested under a strict quality management system. Each batch is characterized to ensure identity, purity, and enantiomeric excess meet the high standards required for catalytic and synthetic applications. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity (by HPLC), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.