Description

4-(2-tert-Butoxycarbonylamino-Ethoxy)-Benzoic Acid is a high-purity, protected amino acid derivative widely used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics. Pharmaceutical R&D laboratories, fine chemical manufacturers, and biotechnology companies need this intermediate for its reliable reactivity and role in facilitating complex coupling reactions under standard Boc-protection strategies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly for peptide-derived therapeutics and small molecule APIs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative, enabling the controlled elongation of peptide chains.
• Linker Molecule: Serves as a versatile spacer or linker in bioconjugation chemistry for attaching functional groups, dyes, or targeting moieties to larger biomolecules.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for amines, making this compound valuable in multi-step synthetic routes requiring selective deprotection.
• Material Science Research: Employed in the development of novel polymers and functional organic materials that require precise incorporation of benzoic acid and protected amine functionalities.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme interactions.

Basic Information

Product Name	4-(2-tert-Butoxycarbonylamino-Ethoxy)-Benzoic Acid
CAS No.	168892-66-8
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	4-[2-[(tert-Butoxycarbonyl)amino]ethoxy]benzoic Acid; 4-(2-Boc-aminoethoxy)benzoic Acid; Boc-NH-(CH2)2-O-Ph-COOH; Benzoic acid, 4-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-; 4-(2-(tert-Butoxycarbonylamino)ethoxy)benzoic Acid; 4-(2-(Boc-amino)ethoxy)benzoic Acid; BOC-AEEA-OH (Benzoic Acid variant); t-Boc-AEEA-Benzoic Acid
EINECS	Contact for details

Quality Control

Our 4-(2-tert-Butoxycarbonylamino-Ethoxy)-Benzoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory documentation requests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.