Description

tert-Butyl (3S)-3-Formyl-1-Oxa-4-Azaspiro[4.5]Decane-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disease treatments.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates.
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients, especially those requiring spirocyclic or proline-like motifs.
• Medicinal Chemistry Research: A valuable scaffold for constructing compound libraries in drug discovery programs targeting protease inhibitors or GPCR modulators.
• Asymmetric Synthesis: Employed in reactions where its aldehyde functionality and protected amine group allow for further selective transformations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl (3S)-3-Formyl-1-Oxa-4-Azaspiro[4.5]Decane-4-Carboxylate
CAS No.	168772-32-5
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	(3S)-3-Formyl-1-Oxa-4-Azaspiro[4.5]Decane-4-Carboxylic Acid tert-Butyl Ester; tert-Butyl (3S)-3-formyl-1-oxa-4-azaspiro[4.5]decane-4-carboxylate; 4-(tert-Butoxycarbonyl)-3-formyl-1-oxa-4-azaspiro[4.5]decane, (3S)-; Boc-Protected 3-Formyl-1-Oxa-4-Azaspiro[4.5]Decane; (S)-tert-Butyl 3-formyl-1-oxa-4-azaspiro[4.5]decane-4-carboxylate; 1-Oxa-4-azaspiro[4.5]decane-4-carboxylic acid, 3-formyl-, 1,1-dimethylethyl ester, (3S)-
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S)-3-Formyl-1-Oxa-4-Azaspiro[4.5]Decane-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment. We support development with custom purity grades and can supply material suitable for use under cGMP guidelines for clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation and moisture uptake. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.