Description

1H-Imidazole-4-Acetic Acid, 1-(Triphenylmethyl)- is a high-purity, protected imidazole derivative of significant interest in advanced organic synthesis. This compound serves as a crucial protected intermediate, enabling the selective functionalization of the imidazole ring system without interference from its reactive nitrogen sites. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex bioactive molecules, including potential drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting enzymes and receptors where the imidazole pharmacophore is essential.
• Agrochemical Research: Used in the development of new fungicides, herbicides, and plant growth regulators that incorporate heterocyclic structures.
• Peptide Mimetics & Bioconjugation: Serves as a protected precursor for introducing imidazole-4-acetic acid motifs into peptides or for creating bioconjugation linkers.
• Material Science: Potential monomer or functional additive in the synthesis of specialty polymers and advanced materials with specific electronic or coordination properties.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes for studying biological processes involving histidine or metal-binding sites.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	1H-Imidazole-4-Acetic Acid, 1-(Triphenylmethyl)-
CAS No.	168632-03-9
Molecular Formula	C24H20N2O2
Molecular Weight	368.43 g/mol
Synonyms	1-Trityl-1H-imidazole-4-acetic acid; 1-(Triphenylmethyl)-1H-imidazole-4-acetic acid; 4-(Carboxymethyl)-1-tritylimidazole; 1H-Imidazole-4-acetic acid, 1-trityl-; Tritylimidazole-4-acetic acid; 1-Tritylimidazole-4-yl-acetic acid; N-Tritylimidazole-4-acetic acid; Protected Imidazole-4-acetic Acid
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Acetic Acid, 1-(Triphenylmethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP (where applicable) requirements. Specifications can be aligned with client-specific protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.