Description

4-Bromo-2,5-difluoronitrobenzene is a versatile and high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique combination of bromine, fluorine, and nitro substituents on the aromatic ring makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in the production of advanced electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups facilitate nucleophilic substitution reactions, allowing for the introduction of various amines, alkoxides, and thiols.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a standard reagent for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	4-Bromo-2,5-difluoronitrobenzene
CAS No.	167415-27-2
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	1-Bromo-4,5-difluoro-2-nitrobenzene; 2,5-Difluoro-4-bromonitrobenzene; Benzene, 1-bromo-4,5-difluoro-2-nitro-; 4-Bromo-2,5-difluoro-1-nitrobenzene; 4-Bromo-2,5-difluoronitrobenzene; 167415-27-2
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,5-difluoronitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.