Description

Cyclohexanamine, 4-(Aminooxy)-, trans- (9Ci) is a specialized chiral amine derivative containing a reactive aminooxy functional group. This compound matters as a high-value building block in advanced organic synthesis, enabling the creation of complex molecules with precise stereochemistry. It is needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as the synthesis of active pharmaceutical ingredients (APIs), chiral ligands, and novel bioactive compounds. Its trans-configuration and bifunctional nature make it a versatile intermediate for constructing heterocycles and functionalized materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific herbicides, fungicides, and plant growth regulators.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing asymmetric catalysts and ligands used in enantioselective synthesis.
• Bioconjugation & Linker Chemistry: The aminooxy group enables efficient oxime ligation for bioconjugation applications in antibody-drug conjugates (ADCs) and diagnostic probes.
• Material Science Research: Employed in the development of functionalized polymers and advanced organic materials with specific stereochemical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and the exploration of new synthetic pathways.

Basic Information

Product Name	Cyclohexanamine, 4-(Aminooxy)-, trans- (9Ci)
CAS No.	167081-01-8
Molecular Formula	C6H14N2O
Molecular Weight	130.19 g/mol
Synonyms	trans-4-(Aminooxy)cyclohexanamine; (1r,4r)-4-(Aminooxy)cyclohexan-1-amine; 4-Aminooxy-trans-cyclohexylamine; 4-(Aminooxy)cyclohexanamine, trans-; 4-(trans-Aminooxy)cyclohexylamine; 4-(Hydroxyamino)cyclohexanamine (trans-); O-(4-Aminocyclohexyl)hydroxylamine (trans-); 1,4-Cyclohexanediamine, 4-(aminooxy)-, trans-
EINECS	Contact for details

Quality Control

Our Cyclohexanamine, 4-(Aminooxy)-, trans- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), chiral excess, and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% trans-isomer
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.