Description

4,4-Dimethyl-7-Ethynyl-1-Tetralone is a high-purity, advanced pharmaceutical intermediate characterized by its unique tetralone core functionalized with an ethynyl group. This compound matters as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry for the development of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) active compounds, oncology treatments, and other specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly those targeting neurological pathways.
• Organic Synthesis Building Block: Used in complex multi-step syntheses, including cross-coupling reactions, due to its reactive ethynyl moiety.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in academic and industrial R&D labs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring a functionalized tetralone structure.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	4,4-Dimethyl-7-Ethynyl-1-Tetralone
CAS No.	166978-48-9
Molecular Formula	C14H14O
Molecular Weight	198.26 g/mol
Synonyms	7-Ethynyl-4,4-dimethyl-1-tetralone; 4,4-Dimethyl-7-ethynyl-3,4-dihydronaphthalen-1(2H)-one; 1(2H)-Naphthalenone, 3,4-dihydro-7-ethynyl-4,4-dimethyl-; Tetralone derivative, 7-ethynyl-4,4-dimethyl-; Building block 166978-48-9
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-7-Ethynyl-1-Tetralone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.