Description

Fmoc-Nh(Ch2)6Nh2 Hcl is a high-purity, protected diamine building block used in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of a hexamethylene diamine spacer into peptide chains, enabling the creation of complex molecular architectures. It is an essential reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and the synthesis of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for introducing a flexible, six-carbon linker (hexamethylene diamine) between peptide segments or functional groups.
• Linker and Spacer Chemistry: Used to create defined-length spacers in the synthesis of peptide-drug conjugates, antibody-drug conjugates (ADCs), and other bioconjugates to optimize pharmacokinetics and activity.
• Combinatorial Chemistry Libraries: Serves as a versatile intermediate for generating diverse compound libraries for high-throughput screening in drug discovery.
• Material Science and Surface Functionalization: Employed to modify surfaces with amine-terminated linkers for biosensor development, microarray fabrication, and biomaterial engineering.
• Dendrimer and Polymer Synthesis: Acts as a branching or chain-extending unit in the controlled synthesis of dendritic macromolecules and functional polymers.

Basic Information

Product Name	Fmoc-Nh(Ch2)6Nh2 Hcl
CAS No.	166410-37-3
Molecular Formula	C₂₂H₂₉N₃O₂ • HCl
Molecular Weight	403.94 g/mol (Free base: 367.49 g/mol)
Synonyms	Fmoc-6-Ahx-NH2 • HCl; Nα-Fmoc-1,6-diaminohexane hydrochloride; N-(9-Fluorenylmethoxycarbonyl)-1,6-diaminohexane hydrochloride; Fmoc-1,6-diaminohexane HCl; Fmoc-hexanediamine hydrochloride; Fmoc-NH-(CH2)6-NH2 • HCl; N-Fmoc-1,6-hexanediamine hydrochloride; Fmoc-Ahx-NH2 • HCl
EINECS	Contact for details

Quality Control

Our Fmoc-Nh(Ch2)6Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.