Description

Fmoc-Nh(Ch2)3Nh2 Hcl is a specialized Fmoc-protected diamine building block, essential for the controlled synthesis of complex molecules. Its primary value lies in providing a reactive primary amine group while the secondary amine is protected, enabling precise, sequential peptide and peptidomimetic assembly. This compound is critically needed by researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates, and in biotechnology for synthesizing custom peptides and protein analogs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of a diamine spacer or linker within peptide chains.
• Peptidomimetic Drug Discovery: Used to incorporate amine-functionalized side chains into non-peptide backbones to enhance bioavailability and metabolic stability.
• Linker Chemistry for Bioconjugation: Serves as a versatile building block for creating heterobifunctional crosslinkers used to attach drugs, labels, or polymers to proteins and antibodies.
• Dendrimer and Polymer Synthesis: Acts as a functional monomer for constructing branched, amine-rich macromolecular architectures.
• Combinatorial Chemistry Libraries: Employed to generate diverse compound libraries for high-throughput screening in medicinal chemistry.
• Protecting Group Strategy in Organic Synthesis: Provides a temporary Fmoc protection for one amine, allowing selective modification of the other in multi-step syntheses.

Basic Information

Product Name	Fmoc-Nh(Ch2)3Nh2 Hcl
CAS No.	166410-34-0
Molecular Formula	C₁₉H₂₃N₂O₂•HCl
Molecular Weight	356.86 g/mol (Free base: 319.40 g/mol)
Synonyms	Fmoc-Dap-OH•HCl; Nα-Fmoc-Nδ-Boc-L-diaminopropionic acid; Fmoc-L-Dap(Boc)-OH; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,3-diaminopropane hydrochloride; N-(9-Fluorenylmethoxycarbonyl)-1,3-diaminopropane hydrochloride; Fmoc-3-amino-propylamine hydrochloride; Fmoc-DAPA hydrochloride
EINECS	Contact for details

Quality Control

Our Fmoc-Nh(Ch2)3Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.