Description

Mono-Fmoc Ethylene Diamine Hydrochloride is a high-purity, protected diamine building block essential for solid-phase peptide synthesis (SPPS). Its primary value lies in providing a selectively protected amine group, allowing for the controlled, sequential elongation of peptide chains. This compound is critically needed by research institutions and pharmaceutical companies engaged in the development of novel peptide therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for introducing an ethylenediamine spacer or linker with orthogonal Fmoc protection.
• Peptide Mimetic Development: Used in the construction of peptide backbones and side chains for creating stable, bioactive analogs.
• Bioconjugation and Linker Chemistry: Serves as a versatile bifunctional linker for attaching peptides, dyes, or drugs to surfaces, polymers, or other biomolecules.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse chemical libraries focused on amine-containing structures for drug discovery screening.
• Protecting Group Strategy: The Fmoc group allows for mild base-deprotection, making it ideal for complex, multi-step syntheses of sensitive peptides.
• Research & Development: Fundamental reagent in academic and industrial R&D for studying protein-protein interactions and developing new biochemical probes.

Basic Information

Product Name	Mono-Fmoc Ethylene Diamine Hydrochloride
CAS No.	166410-32-8
Molecular Formula	C₁₇H₁₉N₂O₂•HCl
Molecular Weight	322.80 g/mol
Synonyms	N-(9-Fluorenylmethoxycarbonyl)ethylenediamine hydrochloride; Fmoc-EDA•HCl; N-Fmoc-1,2-ethanediamine hydrochloride; 1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-aminoethane hydrochloride; Nα-Fmoc-ethylenediamine hydrochloride; (2-Aminoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester hydrochloride; Fmoc-NH-CH2-CH2-NH2•HCl
EINECS	Contact for details

Quality Control

Our Mono-Fmoc Ethylene Diamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.