Description

2-Bromo-4,5-Difluorophenol is a halogenated fluorophenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a valuable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluorophenol moiety can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Acts as a monomer or functionalization agent for engineering plastics and high-performance polymers, imparting flame retardancy and chemical resistance.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Bromo-4,5-Difluorophenol
CAS No.	166281-37-4
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	4,5-Difluoro-2-bromophenol; 2-Bromo-4,5-difluorophenol; Phenol, 2-bromo-4,5-difluoro-; 4,5-Difluoro-2-bromo-1-hydroxybenzene; 2-Bromo-4,5-difluoro-1-hydroxybenzene; 1-Bromo-2-hydroxy-4,5-difluorobenzene; (2-Bromo-4,5-difluorophenyl) alcohol
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4,5-Difluorophenol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and we support custom purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.