Description

2-[2-[2-T-Boc-Aminoethoxy]Ethoxy]Ethyl Bromide is a specialized bifunctional chemical building block featuring a reactive bromoethyl terminus and a protected amine group. This compound is critically important for the controlled synthesis of complex molecules, particularly in the development of pharmaceutical intermediates and advanced polymer conjugates. It is primarily needed by research chemists and process development scientists in the pharmaceutical, bioconjugation, and materials science industries for constructing linker systems and functionalized scaffolds.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring polyethylene glycol (PEG) or spacer-linked functionalities.
• Bioconjugation & Linker Chemistry: Used to create heterobifunctional crosslinkers for attaching drugs, probes, or labels to proteins, antibodies, or other biomolecules.
• Polymer & Dendrimer Synthesis: Serves as a functional monomer or chain extender in the preparation of specialized polymers, dendrimers, and smart materials.
• Solid-Phase Peptide Synthesis (SPPS): Employed to introduce PEG-based spacers or protected amine handles onto peptide chains during synthesis.
• Prodrug Development: Facilitates the construction of cleavable linker systems in prodrugs, enabling targeted drug release.
• Surface Functionalization: Used to modify surfaces (e.g., nanoparticles, chips, beads) with amine-reactive groups for subsequent immobilization chemistry.

Basic Information

Product Name	2-[2-[2-T-Boc-Aminoethoxy]Ethoxy]Ethyl Bromide
CAS No.	165963-71-3
Molecular Formula	C₁₅H₃₀BrNO₅
Molecular Weight	384.31 g/mol
Synonyms	2-[2-(2-{[(tert-Butoxy)carbonyl]amino}ethoxy)ethoxy]ethyl Bromide; N-Boc-NH-PEG2-Br; Boc-NH-PEG2-Br; tert-Butyl N-[2-[2-(2-bromoethoxy)ethoxy]ethyl]carbamate; 2,2'-Ethylenedioxydiethyl Bromide, N-Boc Derivative; Amino-PEG2-Br, Boc-protected; Boc-Amino-PEG2-Br; (Boc-aminoethoxyethoxy)ethyl Bromide
EINECS	Contact for details

Quality Control

Our 2-[2-[2-T-Boc-Aminoethoxy]Ethoxy]Ethyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. The product is sensitive to strong bases and should be kept under inert atmosphere when in prolonged storage to maintain stability. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.