Description

Fmoc-5-Amino-2-Methoxybenzoic Acid is a key protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is specifically designed for the controlled incorporation of a modified tyrosine or phenylalanine analogue into peptide chains, enabling the synthesis of complex biomolecules. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics who require high-purity intermediates for advanced therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial Fmoc-protected building block for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Serves as a linker or functional handle for attaching peptides to other molecules, such as dyes, polymers, or solid surfaces.
• Chemical Biology Probes: Enables the creation of labeled peptides for studying protein-protein interactions and cellular processes.
• Antibody-Drug Conjugate (ADC) Development: A potential component in the synthesis of peptide linkers for targeted cancer therapies.
• Combinatorial Library Synthesis: Used to generate diverse arrays of peptide compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-5-Amino-2-Methoxybenzoic Acid
CAS No.	165073-03-0
Molecular Formula	C23H19NO5
Molecular Weight	389.40 g/mol
Synonyms	Fmoc-5-Amino-2-methoxybenzoic acid; 5-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-2-methoxybenzoic acid; 2-Methoxy-5-[(9-fluorenylmethyloxycarbonyl)amino]benzoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methoxy-5-aminobenzoic acid; N-Fmoc-5-amino-2-methoxybenzoic acid; Fmoc-2-methoxy-5-aminobenzoic acid; 5-(Fmoc-amino)-2-methoxybenzoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-5-Amino-2-Methoxybenzoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.